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Mikhail Blagosklonny Leads the Research for the Most Affordable Yet Effective Cancer Treatment

Mikhail Blagosklonny is an oncologist. He is also a professor who works at the Rosewell Park Cancer Institute of Buffalo in New York. Mikhail is actively involved in finding appropriate cancer therapies. Among his many pieces of research is that of the Rapamycin drug. Rapamycin is also called sirolimus and is a medication that is commonly used for the prevention of organ transplant rejection. It has also been used to manage a rare lung illness as well as to coat coronary stents. It is commonly known by its market name, Rapamune. Besides these uses, Rapamune is also used in cancer treatment.The drug was first isolated in 1972 from a bacterium that was found on Easter Island. At first, it was used as an anti-fungal and over time people realized of its many other benefits. People refer to it as the wonder drug, considering its high anti-proliferative and immunosuppressive properties. When scientists and doctors discovered its other incredible benefits, they abandoned its use as an anti-fungal.When Mikhail realized the many benefits that Rapamycin had, he recommended its use for cancer treatment. He reckons that the drug has a potential for increasing the lifespan of human beings. Blagosklonny’s contribution to the field of science is therefore immense. Some of the other diseases that Rapamycin is used to treat include:

  • Hemolytic-uremic syndrome-the disease arises when a patient suffers from kidney failure, low platelet count, and anemia.
  • Coronary stent coating-Rapamycin is used to coat coronary stents to prevent re-stenosis from reoccurring.
  • Treatment of tuberous sclerosis-it is a congenital disorder that leads to tumor growth in several areas such as the kidneys, heart, and brain.

Mikhail Blagosklonny’s passion

Besides being a doctor, Mikhail is also a great philanthropist and a researcher. He has dedicated his life towards ensuring people from around the globe can access cancer treatment regardless of their economic status. Mikhail is inclined explicitly to studying both cancer and aging. He is interested in understanding how the two are related since cancer is more prevalent in older individuals than younger ones.Mikhail continues to carry out research that is relevant to the field of cancer. Considering how good he is at his job, He has managed to influence both his peers and students who would wish to assist him in the research later on. Cancer is among the most prevalent diseases around the globe today. Therefore, his research has attracted attention, especially within the medical field. It has ever been featured on Mikhail Blagosklonny main aim is to find not only the cure for cancer but also one that can treat the illness efficiently. He works towards developing a treatment option that is not too expensive or excruciating, like most of the cancer treatments on the market today. One of the ways he plans to do this is by finding a drug that can destroy cancerous cells without affecting healthy body cells. He understands that these cells will be vital in recovering the body and mind after several months or years of treatment.

The investment giant that is highland capital management

Highland Capital Management is an investment management firm/ investment advisor that is registered with the Securities and Exchange Commission. It was founded in 1993 by Jim Dondero and Mark Okada. It has been named as one of the largest and most experienced alternative credit managers in the globe.

It has a market value of 2.401 billion dollars on its own and 15.8 billion together with its affiliates.

It has its headquarters in Dallas, Texas. They also have offices in Sao Paolo, Singapore, New York and Seoul.

Highland Capitals Management client’s base includes public pension plans, foundations, endowments, corporations, financial institutions, fund of funds, governments and high net-worth individuals. Their strategies include leveraged loans, high yield bonds, distressed credit, private and public equities, structured products, credit hedge funds, emerging markets and natural resources.

Community Involvement

Highland Capital Management has invested in the communities where their employees reside and work. It aims to make a difference through advisory board involvement, volunteerism and financial donations to both local community organizations and non-profit organizations.

It has made a total of 10 million in donations since the year 2005. An example is the partnership that Highland Capital Management made with the Dallas Foundation to improve North Texas communities in 2016.


Highland Capital Management has invested in different sectors including healthcare, energy, real estate, financials and consumer discretionary.

Michael Gregory who is the Chief Investment Officer has greatly contributed to the company’s financial success by betting on stocks that turned out to be smart investments. Through the Highland Small Cap Equity Fund percentage that was allocated to energy stocks, the company made a huge profit, generating a 32% return for its investors. In fact, all the stocks into which a percentage of the fund was allocated generated a profit except the healthcare sector stocks.

Michael Gregory believes in the healthcare sector. He has a commitment to bettering the healthcare sector by investing in healthcare stocks that not only show promise of gainful returns, but that are good for the people. His dedication is displayed in a statement he made saying that the healthcare sector could make a tremendous rebound in 2017.

Highland Capital Management shows promise of a prosperous future under the careful guidance of Jim Dondero and Michael Gregory.

How IntegraGen’s Publication on Oncotarget Could Help Metastatic Colorectal Cancer Patients

Oncotarget is a free access journal that posts articles on oncology and other related medical fields. Impact Journals published the first Oncotarget journal in 2010. Mikhail Blagosklonny and Andrei Gudkov are the editors-in-chief of the journal. The journal, indexed by PubMed, MEDLINE, and Scopus, is peer-reviewed hence is trustworthy and publishes meaningful content. Oncotarget has had a significant impact in the medical field particularly in the fight against cancer. The journal also covers other disciplines including Cell Biology, Immunology, Cardiology and Neuroscience among others.Scimago Journal and Country Rank give Oncotarget an H Index of 66 and a score of 1.927 to place it among the top five free access oncology journals. This shows how much people love the journal with over six thousand works in 2016 and nearly three hundred thousand references. Oncotarget is the most cited open-access journal with more than twenty-two thousand cites.

IntegraGen, a firm majoring in development of genotypic information and diagnostic tools for oncology, recently published findings of a medical trial they carried out on Oncotarget. The study aims at finding reprieve for patients with metastatic colorectal cancer in both men and women. It is the second most common type of cancer in men and third most common in men. There are more than a million reports of new cases yearly and nearly seven hundred deaths as a result of this type of cancer worldwide each year. One in every four colorectal cancer patients has a metastatic disease at the time of diagnosis with half of these patients developing metastatic colorectal cancer afterward. This type of cancer is responsible for 8.5% of all cancer deaths.IntegraGen launched the study to predict survival chances and possible patient response to anti-EGFR therapy. They analyzed miR-31-3p expression in tumor samples from patients.

This is the first positive theranostic test available for patients. The study confirmed the correlation between miR-31-3p expression and cetuximab usefulness in those with the metastatic colorectal type of cancer. The analysis predicts potential benefits a patient may get when under first-line anti-EGFR therapy as opposed to anti-VEGF treatment. IntegraGen recently launched a ready-to-use kit that quantifies the expression of the miR-31-3p in FFPE tumor samples. Patients do not have to depend solely on chemotherapy as the solution to patients with metastatic colorectal cancer. According to Prof. John Bridgewater, a co-author of the study believes this is another way of identifying patients who will benefit from the new anti-EGFR therapy. The study, therefore, could prove very helpful to metastatic cancer patients as it surely is a better treatment approach. IntegraGen recently reached an agreement with CERBA laboratories to license the development of a lab-developed test that adequately measures the expression of the miR-31-3p in patients with metastatic colorectal cancer.The publication is peer-reviewed thus it provides a meaningful addition to the growing field of research on the need to measure miR-31-3p in tumors from metastatic colorectal cancer patients. With this study and the findings, Yann Gaston-Mathe of IntegraGen believes benefits of precision medicine will soon be realized by many.

Rick Smith-Securus Technologies Brain.

Among the company who have flourished as a result of good leadership is Securus Technologies. Securus Technologies is a high tech company. No designer or company has been able to take their position. Part of their success is as a result of the skills of their CEO, Rick Smith. Rick Smith assumed office in 28th of July. Many people have testified that he was the right individual for the position. This is because of his significant experience in the field. This was to help the company to get rid of the challenges that come along with incompetent leadership.His clean track record, excellent skills, and the rich academic background is what led to his appointment as the leader of the Securus Technologies. The Company has its headquarters in Dallas, Texas. Under the leadership of Rick Smith, the company has been able to provide a variety of services.100000 inmates and 2600 correctional facilities depend on the company for safety. The government and other prominent businesses also depend on Securus Technologies to secure their data.

In terms of experience, Rick Smith is not an amateur. He has been in this field for a long time. This has contributed to his ability to lead the company even in hard economic times. Before working in Securus, he worked in multiple firms. Rick Smith has a very excellent reputation. From 1972 until 1998 he worked with the Global Crossing North America Inc. Here he worked in different departments. This gave him an idea of how the whole system works. This is important because it is the combination of the efforts of every unit that amounts to full success. He later moved to Eschelon Company in 1998.In his first two years, he worked as the chief financial officer. From 2000 to 2003 he served as the company’s president and later became the chief executive officer of the company.

Eschelon Company had seen the potential of Rick Smith. He never let them down. He raised the revenue of the company to $350 million from $30 million.In 2008, Rick Smith was hired by Securus Technologies as president and CEO.After a year, he became the chairman of the company.In terms of the education background, Rick Smith is a learned elite. He attended the State University of New York, Buffalo where he got his Bachelor Degree in Engineering. He also went to Rochester Institute of Technology and its Simon School, where he acquired his master’s degree and MBA respectively. Under his leadership, the company continues to make major steps. The users of their technology have greatly left a great review on their website.Securus Company is responsible for ensuring that public and private safety is maintained. Securus Company makes the state a peaceful place.

Elastic Database Solutions by NuoDB

NuoDB, a database company, located at the Massachusetts was founded in the year 2008. NuoDB has gained recognition from other businesses including Alpha Systems, the UAE Exchange, Dassault Systems and the Gartner Magic Quadrant. Some of these companies apply its technology to.

Upon its launching in 2008, the company’s name was Nimbus. The name was later changed to NuoDB in 2011. NuoDB was co-founded by Barry S. Morris and Jim Starkey. Barry Morris was appointed to the seat of the CEO of the company. The elastically scalable database of the NuoDB was patented through a process that took the company more than a year of struggle. With this, the company was able to gather a total of twelve million dollars in its total ventures.

Cloud applications support the elastic SQL database by the NuoDB. The NuoDB complies well with SQL. Its architecture is distributed object and fits in the cloud. Whenever a new server is introduced into the system to scale out, the database becomes faster. Tasks are distributed to several processors for there to be no bottleneck. The system design aligns appropriately with the IBM rules by Edgar. It is unique in that it can operate anywhere else; it is elastic and scalable and only uses only one logical database.

Why These Two Ingredients In Organo Gold Has Exploded Sales

The healthy coffee, launched by Organo Gold has been around for nearly a decade, but the most interesting note about this healthy drink is what the CEO has been claiming all along; it can benefit the body.

According to a published study in the Annals of Internal Medicine, coffee decreases the risk of coronary heart disease. Clinical studies show that those who drink coffee regularly have fewer strokes, less heart problems, and are less likely to endure cardiovascular diseases.

It’s the most popular drink worldwide and continues to experience rapid growth. With consumers understanding the benefits of coffee, like the antioxidant component, complimented by the infused Ganoderma Lucidem, also called Reishi mushroom, Organo Gold’s healthy coffee has experienced significant popularity.

Organo Gold, developed by Philippine-born CEO, Bernardo Chua, combines premium coffee beans infused with Ganoderma Lucidem, a medicinal Asian mushroom. According to Asian culture, this mushroom can be used to treat allergies, inflammation, heart disease, and more. Coffee is also an antioxidant and contains a magic bullet called Chlorogenic Acid. This ingredient can lower blood sugar levels, resulting in lower fat formation. It also keeps insulin levels balanced.

Chlorogenic acid can inhibit two enzymes in the body, which reduce the absorption of glucose from the diet. This is critical for diabetics. It also increases oxidation, which activates metabolism in the liver, reducing not only body weight but, more importantly, the amount of fat in the body. Organo Gold has capitalized on these facts, and by combining coffee with the Reishi mushroom, the company has developed a heck of a drink.

The company was founded in 2008 by Bernardo Chua, and for nearly a decade Organo Gold has developed a full line of healthy beverages and personal care products. Besides premium coffee, the company also manufacturers green and red tea, hot cocoa, and antioxidant-infused soap.

Headquartered in British Columbia, the company began with one employee exploding with more than 500 workers today, and growing from a one-room office into one of the biggest MLM companies [ranked 55th] nationwide. They became the first coffee company in the United States to infuse a Chinese medicinal element – Reishi – with coffee.

Bernardo Chua, CEO of Organo Gold has built the company into a multi-million dollar firm.

Please follow Organo Gold on Facebook for more information.

IDLife for Ideal Health

If you lack energy and haven’t found a supplement that effectively helps to restore it, turn to IDLife for help. IDLife is a company that can provide you with health and wellness products made just for you. Now you can look and feel your best with supplements that products supply you with the type of nutrition your body really needs.

Products IDLife Offers

IDLife has a nutrition program they customize to fit your nutritional needs. Your nutritional needs are determined after you give IDLife an assessment. As soon as this assessment is evaluated, supplements designed just for you are created and shipped to your door. IDLife also sells morning shakes and vitamin packs designed just for you. They have IDLife hydrating products that supply your body with lost nutrients and electrolytes, and they have products that help you sleep. They also have energy shakes as well as other energy enhancing products, products to manage your weight, and nutritional products for kids. IDLife has skin care products, too. All of the products IDLife creates are free of additives, gluten, and soy. They are Non-GMO. IDLife’s skin care products have been approved by dermatologists, and they are hypoallergenic and free of parabens, sulfates, phthalates, and fragrance.

IDLife’s Chief Executive Officer

Logan Stout is IDLife’s CEO. He has a high regard for health and wellness. In 2014, he gave IDLife its start, and the company has made rapid progress from that point on. Garmin, a company that makes an impressive line of fitness devices, will soon be partnering with IDLife.

If you would like to improve your state of health by taking high quality supplements designed especially for you, start by going to IDLife’s website. Give IDLife a little information about yourself so they can use it to determine your nutritional needs and produce supplements that are best suited for you. Give IDLife information about diet, lifestyle, physical condition, and medical history. Also tell them what medications you are taking. Start taking care of yourself to the best of your ability by using IDLife products.

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Jim Larkin Controversial Stay In U.S. Resulted In Arrest, Pardon, Deportation

In 1919, the First Red Scare began to sweep the United States. It was triggered by the Communist Revolution in Russia and a general fear of anarchism among many sectors of the United States. U.S Government agents reacted by targeting certain individuals whom they considered communist sympathizers and agitators – and a name at the top of the list was that of an Irishman – Jim Larkin.

James “Big Jim” Larkin came to the United States to escape the heat of the many labor strikes and civil unrest he had fomented in his native Ireland. Larkin was an avid union organizer and had played a major role in the infamous 1913 Dublin Lockout.

The Dublin lockout was among the most volatile and painful events in Irish history, pitting some 20,000 workers against the interests of about 300 business owners. After massive strike was finally busted by the wealthy industrial elite, Larkin needed to escape the heat and fled to America.

But if Jim Larkin changed countries, he didn’t change his ways. He joined the Socialist Party of America and became deeply involved with the Industrial Workers of the World union.

This and his open and enthusiastic support for the newly-minted Soviet Union and “agitating” among the American public made him a prime target for U.S. federal agents. Read more; James Larkin | Biography and Jim Larkin | Wikipedia

He was eventually arrested and charged with “criminal anarchy,” convicted and sent to Sing Sing prison to serve a five to 10-year sentence. In 1923, he was pardoned by the governor of New York and deported back to Ireland.

Despite his tumultuous times in America, Jim Larkin enjoys the status of folk hero in his native Ireland today. He is remembered as a champion of the labor movement and a voice for poor, exploited and downtrodden workers. Jim Larkin died in Dublin in 1947.

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Goettl Air Conditioning: Controlling Your World

Whenever you think of a controlled and relaxing air, there is only one thing that should come to mind, Goettl Air Conditioning. One of the most calculated moves by the company was to acquire Walton’s Heating and Air. HVAC earlier owned the company. The company now has a fertile business environment to expand their activities. Goettl which had already established its presence in Las Vegas, Tucson, and Phoenix can now venture in California.

Goettl has a plan of being one of the top brands in the United States of America. The blueprint for this action is laid out. This was re-enforced by their action to acquire the previously owned HVAC Company. Goettl spotted a gap that was not being properly utilized. After a pull and push in the acquirement process, Goettl managed to get its hands on the company. Goettl has ever since promised a better future for itself. The company which was at the time having about 306 employees has promised to add 200 staff. Goodrich has promised to expand to Northern California and venture into Texas by 2018, as stated by Bizjournals.

Goettl Company was founded in 1947. Its headquarters are located in Tempe, Arizona. It majorly deals with AC installation, repairs, and heating services. The current CEO of the company is Ken Goodrich. The CEO can be termed as a life saver. He took over the company while it was still in its infancy form and transformed it into the enigma that it is today. After acquiring the Company, Mr. Goodrich is a customer based entrepreneur as opposed to a money making machine. He has on several occasions cited that Goettl Company is all about making the consumer happy. However, his love for the company has not started recently. Mr. Goodrich was always amazed by how the company stayed strong through his toddler years up to date. Therefore, it is not a surprise that Mr. Goodrich focuses on the consumer since, at a particular point in time, he was one.

Therefore, to make this world a better place, Goettl Company is focused on ensuring energy-saving practices are practiced as much as possible. This can be done by practices such as good AC maintenance. A properly maintained consumes significantly less power. The company also advises on the employment of use of ceiling fans. Also, the company also suggest smarter thinking such as staying cool under a shade instead of using AC during the day. Follow their Twitter page.

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Some of the Splendid Qualities that have Led to Julia Jackson’s Success.

Julia JacksonJulia Jackson possesses various traits that make her an appreciated Jackson Family Wine business proprietor. She is a valuable inclusion to the family wine business. She is also a role model for many women worldwide.Julia is the child of the late Jesse Jackson and Barbara Banke. His father was a legend in the wine business. She did her Bachelor’s Degree in business in ScrippsCollege and continued with her Master’sDegree at Stanford University.She is a very hard working woman who does her best together with others in the firm to ensure that they manufacture unique and quality wine. She developed this work ethic at a tender age in the family. For example, there were days they were motivated by their parents to collect grapes when the temperatures outside were above 100 degrees. The experience laid a good foundation for her. Some of the wine varietals that they offer their customer include Bordeaux, Sauvignon blend, Chardonnay, and others.From her childhood, Julia has had an interest in wine. Therefore, she is more zealous in her job because she is doing something that she loves.

Julia JacksonJulia’s is a very social person and a good marketer. She uses both qualities to present wines produced by Jackson’s firm to various people including celebrities.Some of the celebrities she has interacted and talked with include Lady Gaga, Keira Knightley, Harvey Weinstein, Zac Posen, Jennifer Lopez, Lorraine Toussaint, and many others.Her remarkable personality, business skills, and the broad social network has helped accelerate the family firm a notch higher and produced a bright future for it.Worldwide people celebrate Julia as a great philanthropist. She is the founder of a program called Cambia Seed of Empowerment that motivates women globally. The program shows women who have overcome various challenges and succeeded in their lives. She has also donated funds to various non-profitable organizations that assist women facing adversities.It is a fact that for Julia the sky is not the limit, she is willing to do more to see the Jackson’s Family Wine remain among the best wine supplier. Therefore, her future looks brighter.